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Issues with the brand new biologics are the higher rates and you can organization with infection in addition to tuberculosis. More popular agent try methotrexate with other frequently used representatives as well as sulfasalazine and you can leflunomide. Leflunomide is useful whenever used out of six–12 months, with the same features to methotrexate when used in a couple of years. Sulfasalazine along with seems to be strongest on the quick-term treatment of rheumatoid joint disease.

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